The ANSI X12 committee specified standards for transaction sets, a data element dictionary, and transmission control. Direct comparisons can be found with standards developed in Europe, but the American standards are used differently.
The ANSI X12 standard is used in the USA, Canada and to a degree in Australia. The X12 transaction sets cover a wide range of industry sectors, including administration, education, finance and government:
| Subset Name/Acronym | Industry/Organisation | Comments |
| HL7 | Health Level Seven | The ANSI accredited standards developer for EDI in healthcare environments. Based on the ANSI standards, with the data presented within a default ASCII (American Standards Committee) character set, HL7 is formally accredited by ASC X12, as opposed to a number of communities who have developed their EDI standards based on the X12 syntax, e.g. SPEC 2000. |
| SPEC 2000 | Air Transport Association of America Specification 2000 | Procurement and repair transactions for aircraft maintenance. |
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